The Tafazzin (TAZ) Polyclonal Antibody (CAB12722) is a vital tool for researchers studying Tafazzin, a protein involved in cardiolipin remodeling and mitochondrial function. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Tafazzin protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in the fields of mitochondrial biology and metabolic disorders.Tafazzin, also known as the transacylase enzyme, plays a crucial role in the biosynthesis of cardiolipin, a phospholipid essential for mitochondrial membrane structure and function.
Dysregulation of Tafazzin has been linked to various mitochondrial diseases, including Barth syndrome, highlighting its importance in maintaining cellular health. Research focused on Tafazzin can provide insights into mitochondrial dysfunction and potential therapeutic strategies for treating related disorders.By utilizing the Tafazzin Polyclonal Antibody, researchers can delve deeper into the role of Tafazzin in mitochondrial physiology and explore its implications in disease pathogenesis. This antibody serves as a valuable tool for unraveling the mechanisms underlying mitochondrial dysfunction and offers new avenues for developing targeted treatments for mitochondrial disorders.
Product Name:
Tafazzin/TAZ Rabbit Polyclonal Antibody
SKU:
CAB12722
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 174-248 of human Tafazzin / TAZ (NP_851830.1).
This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
Purification Method:
Affinity purification
Gene ID:
6901
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Tafazzin / TAZ Rabbit pAb (CAB12722) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
