The TAF5L Polyclonal Antibody (PACO43849) is a key tool for researchers studying TAF5L, a transcription initiation factor involved in gene regulation and cell growth. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been rigorously validated for use in Western blot applications. By specifically binding to the TAF5L protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential reagent for studies in molecular biology and cancer research.TAF5L is a crucial component of the transcription machinery, supporting the initiation of RNA synthesis and the regulation of gene expression.
Its role in controlling cellular processes underscores its importance in understanding developmental pathways, disease mechanisms, and potential therapeutic targets. The TAF5L Polyclonal Antibody offers researchers a valuable tool to explore the functions and interactions of TAF5L in various biological contexts, paving the way for advancements in diverse fields such as genetics, oncology, and drug discovery.
Antibody Name:
TAF5L Antibody (PACO43849)
Antibody SKU:
PACO43849
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L protein (1-325AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43849 at dilution of 1:100.
Background:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.
TAF5L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the WD repeat TAF5 family. 2 isoforms of the human protein are produced by alternative splicing.
Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
NCBI Summary:
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
