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TAF5L Antibody (PACO12627)

SKU:
PACO12627
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
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Description

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TAF5L Antibody (PACO12627)

The TAF5L Polyclonal Antibody (PAC012627) is a valuable tool for researchers studying TAF5L, a key component of the TFIID complex involved in transcriptional regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the TAF5L protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and gene expression studies.TAF5L plays a crucial role in gene expression by facilitating the assembly of the pre-initiation complex, which is essential for transcription initiation. Its involvement in regulating gene activity implicates TAF5L in numerous biological processes, including development, cell growth, and differentiation.

Researchers can use this antibody to explore the functions of TAF5L and its implications in various physiological and pathological conditions, such as cancer, development disorders, and metabolic diseases.By uncovering the mechanisms of TAF5L action, scientists can gain insights into gene regulation and potentially identify therapeutic targets for treating disorders linked to dysregulated gene expression. The TAF5L Polyclonal Antibody is a valuable tool for elucidating the role of TAF5L in cellular processes and advancing our understanding of transcriptional control mechanisms.

Antibody Name:TAF5L Antibody (PACO12627)
Antibody SKU:PACO12627
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human TAF5L
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa;TAF5L;PAF65B ;
UniProt Protein Function:TAF5L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the WD repeat TAF5 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 1q42.13

Molecular Function:histone acetyltransferase activity; protein binding; transcription coactivator activity; transcription factor activity

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter

NCBI Summary:The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O75529
NCBI GenInfo Identifier:46577305
NCBI Gene ID:27097
NCBI Accession:O75529.1
UniProt Secondary Accession:O75529,Q5TDI5, Q5TDI6, Q8IW31,
UniProt Related Accession:O75529
Molecular Weight:36,991 Da
NCBI Full Name:TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
NCBI Synonym Full Names:TATA-box binding protein associated factor 5 like
NCBI Official Symbol:TAF5L  
NCBI Official Synonym Symbols:PAF65B  
NCBI Protein Information:TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
UniProt Protein Name:TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
UniProt Synonym Protein Names:PCAF-associated factor 65 beta; PAF65-beta
Protein Family:TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor
UniProt Gene Name:TAF5L  
UniProt Entry Name:TAF5L_HUMAN

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