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TAF4/TAF4B Antibody (PACO05166)

SKU:
PACO05166
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€319

Description

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TAF4/TAF4B Antibody (PACO05166)

The TAF4/TAF4B Polyclonal Antibody (PACO05166) is a powerful tool for research involving the TAF4 and TAF4B proteins, which are essential components of the TFIID complex involved in transcription initiation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to TAF4 and TAF4B, this antibody enables researchers to detect and analyze these proteins in various cell types, making it a valuable tool for studies in molecular biology and gene expression regulation.TAF4 and TAF4B are key players in the complex machinery of gene transcription, playing crucial roles in regulating gene expression and controlling essential cellular processes.

Understanding the functions and interactions of these proteins is vital for unraveling the complexities of gene regulation and identifying potential therapeutic targets for various diseases, including cancer and genetic disorders. The TAF4/TAF4B Polyclonal Antibody provides researchers with a reliable means to investigate the functions of TAF4 and TAF4B, ultimately advancing our knowledge of gene regulation mechanisms and potential treatment options for related diseases.

Antibody Name:TAF4/TAF4B Antibody (PACO05166)
Antibody SKU:PACO05166
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from the C-terminal region of human TAF II p135/p105.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TAF4; TAF2C; TAF2C1; TAF4A; TAFII130; TAFII135; Transcription initiation factor TFIID subunit 4; RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130;
UniProt Protein Function:TAF4: Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Belongs to the TAF4 family.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: cytoplasm; nucleoplasm; transcription factor TFIID complex

Molecular Function:DNA binding; protein binding; transcription coactivator activity; transcription factor activity

Biological Process: positive regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation; transcription initiation from RNA polymerase II promoter

NCBI Summary:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
UniProt Code:O00268
NCBI GenInfo Identifier:56405299
NCBI Gene ID:6874
NCBI Accession:O00268.2
UniProt Secondary Accession:O00268,Q5TBP6, Q99721, Q9BR40, Q9BX42, A6NGD9,
UniProt Related Accession:O00268
Molecular Weight:110114 Da
NCBI Full Name:Transcription initiation factor TFIID subunit 4
NCBI Synonym Full Names:TATA-box binding protein associated factor 4
NCBI Official Symbol:TAF4  
NCBI Official Synonym Symbols:TAF2C; TAF4A; TAF2C1; TAFII130; TAFII135  
NCBI Protein Information:transcription initiation factor TFIID subunit 4
UniProt Protein Name:Transcription initiation factor TFIID subunit 4
UniProt Synonym Protein Names:RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130; TAFII-130; TAFII130; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135; TAFII135
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF4  
UniProt Entry Name:TAF4_HUMAN

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