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TAF4 Antibody (PACO21673)

SKU:
PACO21673
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$527

Description

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TAF4 Antibody (PACO21673)

The TAF4 Polyclonal Antibody (PAC021673) is a valuable tool for researchers studying the transcription initiation factor TAF4, a key component of the TFIID complex involved in RNA polymerase II-mediated gene transcription. This antibody, developed in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as immunohistochemistry and flow cytometry.TAF4 plays a crucial role in gene regulation and has been implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis. By targeting the TAF4 protein, this antibody enables precise detection and analysis of TAF4 expression in different cell types, offering researchers insights into its functions and potential therapeutic applications in the fields of genetics, epigenetics, and cancer research.

Furthermore, understanding the mechanisms underlying TAF4 activity is essential for unraveling its contribution to transcriptional control and gene expression regulation, laying the groundwork for developing innovative strategies to manipulate TAF4 function for therapeutic benefit. The TAF4 Polyclonal Antibody is an indispensable tool for advancing research in molecular biology and uncovering new avenues for treating genetic disorders and cancer.

Antibody Name:TAF4 Antibody (PACO21673)
Antibody SKU:PACO21673
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human TAF4.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from NIH-3T3 cells, using TAF4 antibody.
Background:Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Deloukas P., Nature 414:865-871(2001).
Synonyms:Transcription initiation factor TFIID subunit 4; TBP-associated factor 4; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135
UniProt Protein Function:TAF4: Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Belongs to the TAF4 family.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: cytoplasm; nucleoplasm; transcription factor TFIID complex

Molecular Function:DNA binding; protein binding; transcription coactivator activity; transcription factor activity

Biological Process: positive regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation; transcription initiation from RNA polymerase II promoter

NCBI Summary:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
UniProt Code:O00268
NCBI GenInfo Identifier:56405299
NCBI Gene ID:6874
NCBI Accession:O00268.2
UniProt Secondary Accession:O00268,Q5TBP6, Q99721, Q9BR40, Q9BX42, A6NGD9,
UniProt Related Accession:O00268
Molecular Weight:110114 Da
NCBI Full Name:Transcription initiation factor TFIID subunit 4
NCBI Synonym Full Names:TATA-box binding protein associated factor 4
NCBI Official Symbol:TAF4  
NCBI Official Synonym Symbols:TAF2C; TAF4A; TAF2C1; TAFII130; TAFII135  
NCBI Protein Information:transcription initiation factor TFIID subunit 4
UniProt Protein Name:Transcription initiation factor TFIID subunit 4
UniProt Synonym Protein Names:RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130; TAFII-130; TAFII130; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135; TAFII135
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF4  
UniProt Entry Name:TAF4_HUMAN
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