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TAF1A Antibody (PACO05664)

SKU:
PACO05664
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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TAF1A Antibody (PACO05664)

The TAF1A Polyclonal Antibody (PACO05664) is a valuable tool for researchers studying TAF1A, a key protein involved in transcriptional regulation. This antibody, produced in rabbits, shows strong reactivity with human samples and has been verified for use in Western blot experiments. By binding to TAF1A, this antibody enables researchers to detect and analyze the protein in a variety of cell types, making it a versatile tool for investigations in molecular biology and gene expression studies.TAF1A, also known as TATA box-binding protein-associated factor 1A, plays a crucial role in the assembly of transcription initiation complexes and regulation of gene expression.

Its involvement in these fundamental cellular processes makes TAF1A a target of interest for research into gene regulation, cellular differentiation, and development. Understanding the function and regulation of TAF1A is essential for unraveling the complex mechanisms governing gene expression and cellular function in various biological systems.

Antibody Name:TAF1A Antibody (PACO05664)
Antibody SKU:PACO05664
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Rat
Immunogen:Synthesized peptide derived from the Internal region of human TAF I p48.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TAF1A; TATA box-binding protein-associated factor RNA polymerase I subunit A; RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1;
UniProt Protein Function:TAF1A: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q42

Cellular Component: intracellular membrane-bound organelle; microtubule cytoskeleton; nucleoplasm; nucleus; RNA polymerase I transcription factor complex

Molecular Function:protein binding

Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter

NCBI Summary:This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
UniProt Code:Q15573
NCBI GenInfo Identifier:74739864
NCBI Gene ID:9015
NCBI Accession:Q15573.1
UniProt Secondary Accession:Q15573,Q9NWA1, B2RDZ8, D3DTB7,
UniProt Related Accession:Q15573
Molecular Weight:39,615 Da
NCBI Full Name:TATA box-binding protein-associated factor RNA polymerase I subunit A
NCBI Synonym Full Names:TATA-box binding protein associated factor, RNA polymerase I subunit A
NCBI Official Symbol:TAF1A  
NCBI Official Synonym Symbols:SL1; RAFI48; TAFI48; MGC:17061  
NCBI Protein Information:TATA box-binding protein-associated factor RNA polymerase I subunit A
UniProt Protein Name:TATA box-binding protein-associated factor RNA polymerase I subunit A
UniProt Synonym Protein Names:RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1; Transcription initiation factor SL1/TIF-IB subunit A
Protein Family:TATA box-binding protein-associated factor
UniProt Gene Name:TAF1A  
UniProt Entry Name:TAF1A_HUMAN

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