The TADA2B Polyclonal Antibody (PACO37230) is a valuable tool for researchers studying TADA2B, a transcriptional adaptor protein involved in chromatin remodeling and gene regulation. This antibody, produced in rabbits, is highly specific for human TADA2B and has been validated for use in Western blot applications.TADA2B plays a crucial role in the regulation of gene expression by promoting the assembly of transcriptional complexes and enhancing histone acetylation. Dysregulation of TADA2B has been linked to various diseases, including cancers and neurological disorders, making it an important target for investigation in biomedical research.
By utilizing the TADA2B Polyclonal Antibody, researchers can effectively detect and analyze TADA2B protein levels in a variety of cell types, aiding in the understanding of its functions in different cellular contexts. This antibody is a valuable tool for studies in molecular biology, cancer research, and epigenetics, providing valuable insights into the mechanisms underlying TADA2B-mediated gene regulation.
Antibody Name:
TADA2B Antibody (PACO37230)
Antibody SKU:
PACO37230
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Transcriptional adapter 2-β protein (29-328AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO37230 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO37230 at dilution of 1:100.
Background:
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.
Synonyms:
Transcriptional adapter 2-β (ADA2-like protein beta) (ADA2-beta), TADA2B, ADA2B
UniProt Protein Function:
TADA2B: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:DNA-binding; Transcription, coactivator/corepressor
Biological Process: chromatin remodeling; positive regulation of histone acetylation; regulation of transcription from RNA polymerase II promoter
NCBI Summary:
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
