The TADA2A Polyclonal Antibody (CAB8457) is a vital tool for researchers studying the TADA2A protein, a key player in gene regulation and chromatin remodeling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to TADA2A, this antibody allows for precise detection and analysis of the protein in various cell types, making it indispensable for studies in molecular biology and epigenetics.TADA2A is a crucial component of the ADA2A-containing complex, which is involved in histone acetylation and gene transcription regulation.
Dysregulation of TADA2A has been implicated in various diseases, including cancer and neurological disorders. Understanding the function and regulation of TADA2A is essential for unraveling its role in disease pathogenesis and identifying potential therapeutic targets.Researchers in the fields of genetics, oncology, and neurobiology will find the TADA2A Polyclonal Antibody (CAB8457) to be a valuable asset in their investigations, providing accurate and reliable detection of TADA2A protein levels and enabling deeper insights into its biological mechanisms.
Product Name:
TADA2A Rabbit Polyclonal Antibody
SKU:
CAB8457
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-443 of human TADA2A (NP_001159577.2).
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
6871
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TADA2A antibody (CAB8457) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
