TAB3 Rabbit Polyclonal Antibody (CAB18681)
- SKU:
- CAB18681
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TAB3 Rabbit Polyclonal Antibody |
SKU: | CAB18681 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 390-480 of human TAB3 (NP_690000.3). |
Sequence: | QPSP RNQH SLYT ATTP PSSS PSRG ISSQ PKPP FSVN PVYI TYTQ PTGP SCTP SPSP RVIP NPTT VFKI TVGR ATTE NLLN LVDQ EERS AAP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | NAP1; MAP3K7IP3; TAB3 |
Positive Sample: | HepG2,Mouse spleen,Mouse heart,Rat testis |
Cellular Localization: | cytosol, extracellular exosome, plasma membrane |
Calculated MW: | 79kDa |
Observed MW: | 100kDa |
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 257397 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |