The TAB3 Polyclonal Antibody (CAB18681) is a powerful tool for researchers studying the TAB3 protein, a key player in inflammatory signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity for TAB3 in human samples, making it ideal for Western blotting applications. By targeting the TAB3 protein, this antibody allows for the precise detection and analysis of TAB3 expression in various cell types, providing valuable insights into its role in immune responses and inflammation.TAB3 is a critical component of the TAK1 signaling complex, which plays a crucial role in mediating responses to pro-inflammatory cytokines and stress signals. By modulating TAK1 activity, TAB3 influences downstream signaling pathways that regulate inflammatory gene expression.
Research into the function of TAB3 is vital for understanding the molecular mechanisms underlying inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease, and for identifying potential therapeutic targets for these conditions.In conclusion, the TAB3 Polyclonal Antibody (CAB18681) is a valuable tool for researchers investigating the roles of TAB3 in inflammatory signaling pathways. Its high specificity and sensitivity make it an ideal choice for studies in immunology, inflammation, and related fields, providing essential insights that could lead to the development of novel therapeutic strategies for inflammatory diseases.
Product Name:
TAB3 Rabbit Polyclonal Antibody
SKU:
CAB18681
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 390-480 of human TAB3 (NP_690000.3).
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
257397
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TAB3 pAb (CAB18681) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
