TAB2 Rabbit Polyclonal Antibody (CAB9867)
- SKU:
- CAB9867
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | TAB2 Rabbit Polyclonal Antibody |
SKU: | CAB9867 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-620 of human TAB2 (NP_055908.1). |
Sequence: | TLAH VDRI SETR KLSM GSDD AAYT QALL VHQK ARME RLQR ELEI QKKK LDKL KSEV NEME NNLT RRRL KRSN SISQ IPSL EEMQ QLRS CNRQ LQID IDCL TKEI DLFQ ARG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CHTD2; TAB-2; MAP3K7IP2; TAB2 |
Positive Sample: | Mouse brain,Mouse heart,Rat skeletal muscle,Rat kidney,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Peripheral membrane protein, cytosol. |
Calculated MW: | 76kDa |
Observed MW: | 80kDa |
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 23118 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |