TAB1 Rabbit Polyclonal Antibody (CAB5749)
- SKU:
- CAB5749
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | TAB1 Rabbit Polyclonal Antibody |
SKU: | CAB5749 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 205-504 of human TAB1 (NP_006107.1). |
Sequence: | VDHT TENE DELF RLSQ LGLD AGKI KQVG IICG QEST RRIG DYKV KYGY TDID LLSA AKSK PIIA EPEI HGAQ PLDG VTGF LVLM SEGL YKAL EAAH GPGQ ANQE IAAM IDTE FAKQ TSLD AVAQ AVVD RVKR IHSD TFAS GGER ARFC PRHE DMTL LVRN FGYP LGEM SQPT PSPA PAAG GRVY PVSV PYSS AQST SKTS VTLS LVMP SQGQ MVNG AHSA STLD EATP TLTN QSPT LTLQ STNT HTQS SSSS SDGG LFRS RPAH SLPP GEDG RVEP YVDF AEFY RLWS VDHG EQSV VTAP |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:10 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | 3'-Tab1; MAP3K7IP1; TAB1 |
Positive Sample: | HL-60,MCF7,A-431,U-251MG,HeLa,Mouse kidney,Mouse heart,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nuclear speck, nucleus |
Calculated MW: | 55kDa |
Observed MW: | 70kDa |
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 10454 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |