TAB1 Antibody (PACO20833)
- SKU:
- PACO20833
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TAB1 Antibody (PACO20833)
The TAB1 Antibody (PAC020833) is a valuable tool for research involving TAB1, a key signaling molecule in the TAK1 pathway that regulates cellular responses to stress and inflammation. This polyclonal antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to TAB1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in signal transduction and inflammatory pathways.TAB1, also known as TAK1-binding protein 1, plays a crucial role in regulating the activation of TAK1 and downstream signaling cascades in response to cellular stress and inflammatory stimuli.
Its involvement in these pathways makes it a promising target for research into diseases such as cancer, inflammatory disorders, and autoimmune conditions. Understanding the function of TAB1 is essential for developing targeted therapies that can modulate signaling pathways and address pathologies associated with dysregulated inflammation and immune responses.
| Antibody Name: | TAB1 Antibody (PACO20833) |
| Antibody SKU: | PACO20833 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human TAB1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20833(TAB1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF β receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Synonyms: | TGF-β activated kinase 1/MAP3K7 binding protein 1 |
| UniProt Protein Function: | TAB1: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Activator; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; protein complex; cytoplasm; endosome membrane; cytosol Molecular Function:protein binding; mitogen-activated protein kinase p38 binding; enzyme activator activity; protein complex binding; kinase activator activity; catalytic activity Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; transforming growth factor beta receptor signaling pathway; toll-like receptor signaling pathway; activation of MAPKKK activity; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; lung development |
| NCBI Summary: | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15750 |
| NCBI GenInfo Identifier: | 10720303 |
| NCBI Gene ID: | 10454 |
| NCBI Accession: | Q15750.1 |
| UniProt Secondary Accession: | Q15750,Q2PP09, Q8IZW2, |
| UniProt Related Accession: | Q15750 |
| Molecular Weight: | 504 |
| NCBI Full Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
| NCBI Synonym Full Names: | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| NCBI Official Symbol: | TAB1Â Â |
| NCBI Official Synonym Symbols: | 3'-Tab1; MAP3K7IP1Â Â |
| NCBI Protein Information: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1 |
| UniProt Protein Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
| UniProt Synonym Protein Names: | Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1 |
| Protein Family: | TGF-beta-activated kinase 1 and MAP3K7-binding protein |
| UniProt Gene Name: | TAB1Â Â |
| UniProt Entry Name: | TAB1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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