TAB1 Rabbit Monoclonal Antibody (CAB3306)
- SKU:
- CAB3306
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- 3'-Tab1
- MAP3K7IP1
- Research Area:
- Cell Biology
Description
Product Name: | TAB1 Rabbit Monoclonal Antibody |
SKU: | CAB3306 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 405-504 of human TAB1 (Q15750). |
Sequence: | VTLS LVMP SQGQ MVNG AHSA STLD EATP TLTN QSPT LTLQ STNT HTQS SSSS SDGG LFRS RPAH SLPP GEDG RVEP YVDF AEFY RLWS VDHG EQSV VTAP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | 3'-Tab1; MAP3K7IP1; TAB1 |
Positive Sample: | HeLa,293T,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nuclear speck, nucleus |
Calculated MW: | 55kDa |
Observed MW: | 55kDa |
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 10454 |
Clone Number: | ARC1943 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |