SZT2 Antibody (PACO50654)
- SKU:
- PACO50654
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SZT2 Antibody (PACO50654)
The SZT2 Antibody (PAC050654) is a highly specific and sensitive tool for research focused on SZT2, a protein involved in cellular processes related to microtubule organization and cell division. This polyclonal antibody, generated against SZT2 in rabbits, exhibits strong reactivity with human samples and is suitable for Western blot applications. By binding to SZT2, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and cancer research.
SZT2 is a key player in maintaining genome stability and proper spindle formation during cell division, making it essential for normal cellular functions. Dysregulation of SZT2 has been associated with various diseases, including cancer, neurodevelopmental disorders, and reproductive disorders. Investigating the role and regulation of SZT2 is crucial for advancing our understanding of these conditions and developing targeted therapies to address them.
| Antibody Name: | SZT2 Antibody (PACO50654) |
| Antibody SKU: | PACO50654 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein SZT2 protein (2396-2517AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO50654 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO50654 at dilution of 1:100. |
| Background: | Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold (By similarity). |
| Synonyms: | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog), SZT2, C1orf84 KIAA0467 |
| UniProt Protein Function: | SZT2: Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 1p34.2Cellular Component: peroxisomeBiological Process: central nervous system development; pigmentation; corpus callosum morphogenesis; post-embryonic developmentDisease: Epileptic Encephalopathy, Early Infantile, 18 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q5T011 |
| NCBI GenInfo Identifier: | 31127243 |
| NCBI Gene ID: | 23334 |
| NCBI Accession: | BC052802 |
| UniProt Secondary Accession: | Q5T011,O75055, Q5JUY7, Q5T012, Q5XKC7, Q6ZNI8, Q6ZT24 Q7Z636, Q8NAY9, Q9H5H7 |
| UniProt Related Accession: | Q5T011 |
| Molecular Weight: | 20,286 Da |
| NCBI Full Name: | Homo sapiens KIAA0467, mRNA |
| NCBI Synonym Full Names: | seizure threshold 2 homolog (mouse) |
| NCBI Official Symbol: | SZT2Â Â |
| NCBI Official Synonym Symbols: | SZT2A; SZT2B; EIEE18; C1orf84; KIAA0467Â Â |
| NCBI Protein Information: | protein SZT2; RP11-506B15.1; seizure threshold 2 protein homolog |
| UniProt Protein Name: | Protein SZT2 |
| UniProt Synonym Protein Names: | Seizure threshold 2 protein homolog |
| Protein Family: | Protein |
| UniProt Gene Name: | SZT2Â Â |
| UniProt Entry Name: | SZT2_HUMAN |
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