The SYVN1 Polyclonal Antibody (CAB2605) is a valuable tool for researchers studying SYVN1, a key player in protein quality control and degradation pathways within cells. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SYVN1 protein, this antibody allows for the detection and analysis of SYVN1 levels in a variety of cell types.SYVN1, also known as synoviolin, is involved in the endoplasmic reticulum-associated degradation (ERAD) pathway, which is responsible for removing misfolded proteins from the cell.
Dysregulation of SYVN1 has been implicated in various diseases, including neurodegenerative disorders and cancer. Therefore, understanding the role of SYVN1 in protein degradation processes is crucial for developing targeted therapies for these conditions.Overall, the SYVN1 Polyclonal Antibody (CAB2605) is a valuable tool for researchers interested in exploring the functions of SYVN1 and its potential implications in human health and disease.
Product Name:
SYVN1 Rabbit Polyclonal Antibody
SKU:
CAB2605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SYVN1 (NP_757385.1).
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
Purification Method:
Affinity purification
Gene ID:
84447
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of U2OS, using SYVN1 Rabbit pAb (CAB2605) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
