SYT2 Antibody (PACO18437)
- SKU:
- PACO18437
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SYT2 Antibody (PACO18437)
The SYT2 Polyclonal Antibody (PAC018437) is a valuable tool for researchers studying Synaptotagmin-2 (SYT2), a protein involved in synaptic vesicle trafficking and neurotransmitter release in the brain. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot and immunofluorescence applications.SYT2 is essential for controlling the release of neurotransmitters in neurons, making it a key player in synaptic communication and neuronal function. Dysregulation of SYT2 has been implicated in various neurological disorders, including epilepsy and Parkinson's disease, highlighting its importance in understanding brain function and disease pathogenesis.
With the SYT2 Polyclonal Antibody, researchers can accurately detect and analyze SYT2 expression in neuronal cells, providing valuable insights into the mechanisms underlying neurotransmission. This antibody is an essential tool for studies in neuroscience, drug discovery, and the development of therapies targeting neurological disorders.
| Antibody Name: | SYT2 Antibody (PACO18437) |
| Antibody SKU: | PACO18437 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SYT2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, Human lung tissue, Primary antibody: PACO18437(SYT2 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
| Background: | Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene. Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acid, c phospholipids with a specificity that requires the presence of both an acid, c head group and a diacyl backbone. |
| Synonyms: | synaptotagmin II |
| UniProt Protein Function: | SYT2: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. Belongs to the synaptotagmin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Lipid-binding; Vesicle; Calcium-binding Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: intracellular membrane-bound organelle; synaptic vesicle membrane; plasma membrane; integral to membrane; cell junction Molecular Function:protein binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding Biological Process: transport; pathogenesis Disease: Myasthenic Syndrome, Presynaptic, Congenital, With Or Without Motor Neuropathy |
| NCBI Summary: | This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q8N9I0 |
| NCBI GenInfo Identifier: | 116242811 |
| NCBI Gene ID: | 127833 |
| NCBI Accession: | Q8N9I0.2 |
| UniProt Secondary Accession: | Q8N9I0,Q496K5, Q8NBE5, |
| UniProt Related Accession: | Q8N9I0 |
| Molecular Weight: | 419 |
| NCBI Full Name: | Synaptotagmin-2 |
| NCBI Synonym Full Names: | synaptotagmin II |
| NCBI Official Symbol: | SYT2Â Â |
| NCBI Official Synonym Symbols: | MYSPC; SytIIÂ Â |
| NCBI Protein Information: | synaptotagmin-2 |
| UniProt Protein Name: | Synaptotagmin-2 |
| UniProt Synonym Protein Names: | Synaptotagmin II; SytII |
| Protein Family: | Synaptotagmin |
| UniProt Gene Name: | SYT2Â Â |
| UniProt Entry Name: | SYT2_HUMAN |
Related Products
SYT1/SYT2 Antibody (PACO01562)
SYT1/SYT2 Antibody (PACO01563)
Phospho-SYT1/SYT2 (Thr202/199) Antibody (PACO23871)
Phospho-SYT1/SYT2 (S309/306) Antibody (PACO00294)
