The SYT12 Polyclonal Antibody (CAB17241) is a valuable tool for researchers studying SYT12, a synaptotagmin protein involved in synaptic vesicle exocytosis and neurotransmitter release. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the SYT12 protein, this antibody allows for the detection and analysis of SYT12 in various cell types, making it ideal for studies in neuroscience and neurobiology.
SYT12 is a key player in the regulation of synaptic transmission and plasticity, making it essential for understanding brain function and neurological disorders. Research on SYT12 has implications for diseases such as Parkinson's disease, Alzheimer's disease, and epilepsy, where synaptic dysfunction plays a critical role. By studying the role of SYT12, researchers can uncover new therapeutic targets and treatments for these debilitating conditions.
Product Name:
SYT12 Rabbit Polyclonal Antibody
SKU:
CAB17241
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 95-200 of human SYT12 (NP_001171351.1).
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.
Purification Method:
Affinity purification
Gene ID:
91683
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using SYT12 Rabbit pAb (CAB17241) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
