The SYT10 Polyclonal Antibody (PAC036986) is a valuable tool for researchers studying SYT10, a member of the synaptotagmin family of proteins that plays a key role in neurotransmitter release and synaptic vesicle fusion. This antibody, raised in rabbits, is highly specific to the human SYT10 protein and has been validated for use in Western blot applications.SYT10 is known to be involved in the regulation of calcium-dependent exocytosis in neurons, making it a crucial player in synaptic transmission and neuronal communication. Dysregulation of SYT10 function has been implicated in various neurological disorders, making it a promising target for therapeutic interventions.
By using the SYT10 Polyclonal Antibody, researchers can accurately detect and analyze SYT10 protein levels in different cell types and tissues, providing valuable insights into its function and potential roles in diseases such as Alzheimer's, Parkinson's, and other neurodegenerative conditions. This antibody is a valuable tool for furthering our understanding of synaptic function and the development of targeted therapies for neurological disorders.
Antibody Name:
SYT10 Antibody (PACO36986)
Antibody SKU:
PACO36986
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Synaptotagmin-10 protein (301-523AA)
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO36986 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO36986 at dilution of 1:100.
Background:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Synonyms:
Synaptotagmin-10 (Synaptotagmin X) (SytX), SYT10
UniProt Protein Function:
SYT10: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.Protein type: Membrane protein, integral; Calcium-binding; VesicleChromosomal Location of Human Ortholog: 12p11.1Cellular Component: cell junction; integral to membrane; synaptic vesicle membraneMolecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein heterodimerization activity; protein homodimerization activity; syntaxin bindingBiological Process: regulation of calcium ion-dependent exocytosis
