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SYT1/SYT2 Antibody (PACO01562)

SKU:
PACO01562
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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SYT1/SYT2 Antibody (PACO01562)

The SYT1/SYT2 Antibody (PACO01562) is a polyclonal antibody designed for research involving the synaptotagmin 1 (SYT1) and synaptotagmin 2 (SYT2) proteins, which are important regulators of synaptic vesicle exocytosis in neurons. The antibody, raised in rabbits, is highly specific and reactive with human, mouse, and rat samples, making it versatile for studies in neuroscience and neurobiology.SYT1 and SYT2 are crucial for calcium-dependent neurotransmitter release at synaptic terminals, playing a key role in synaptic transmission and plasticity.

As such, understanding the function and regulation of these proteins is essential for deciphering the mechanisms underlying neuronal communication and synaptic plasticity in the brain. The SYT1/SYT2 Antibody enables detection and analysis of these proteins in various experimental settings, including Western blot and immunofluorescence applications, making it a valuable tool for researchers studying synaptic transmission and neurological disorders.

Antibody Name:SYT1/SYT2 Antibody
Antibody SKU:PACO01562
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Synaptotagmin 1/2 around the non-phosphorylation site of S309/306.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:SYT1; SVP65; SYT; Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT2; Synaptotagmin-2; Synaptotagmin II; SytII
UniProt Protein Function:SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle; Calcium-binding

Chromosomal Location of Human Ortholog: 12cen-q21

Cellular Component: neuron projection; plasma membrane; synaptic vesicle; synaptic vesicle membrane

Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SNARE binding; syntaxin-1 binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; detection of calcium ion; glutamate secretion; neurotransmitter secretion; positive regulation of synaptic transmission; protein homooligomerization; regulation of calcium ion-dependent exocytosis; regulation of exocytosis; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic vesicle endocytosis; vesicle fusion

NCBI Summary:The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
UniProt Code:P21579
NCBI GenInfo Identifier:135086
NCBI Gene ID:6857
NCBI Accession:P21579.1
UniProt Secondary Accession:P21579,Q6AI31,
UniProt Related Accession:P21579
Molecular Weight:47,573 Da
NCBI Full Name:Synaptotagmin-1
NCBI Synonym Full Names:synaptotagmin 1
NCBI Official Symbol:SYT1  
NCBI Official Synonym Symbols:P65; SYT; SVP65  
NCBI Protein Information:synaptotagmin-1
UniProt Protein Name:Synaptotagmin-1
UniProt Synonym Protein Names:Synaptotagmin I; SytI; p65
Protein Family:Synaptotagmin
UniProt Gene Name:SYT1  
UniProt Entry Name:SYT1_HUMAN

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