SYT1/SYT2 (Ab-202/199) Antibody (PACO22975)
- SKU:
- PACO22975
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SYT1/SYT2 (Ab-202/199) Antibody (PACO22975)
The SYT1/SYT2 AB 202-199 Antibody (PAC022975) is a valuable tool for research involving synaptic proteins SYT1 and SYT2. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in various applications such as Western blot and immunofluorescence.SYT1 and SYT2 are critical proteins involved in synaptic vesicle exocytosis and neurotransmitter release, making them essential for proper synaptic function and neuronal communication. The SYT1/SYT2 AB 202-199 Antibody facilitates the detection and analysis of these proteins in different cell types, providing valuable insights into their roles in neuronal signaling and synaptic transmission.
Research into SYT1 and SYT2 is crucial for understanding neurological disorders and conditions affecting synaptic function, such as Alzheimer's disease, Parkinson's disease, and epilepsy. By studying the activity and function of these proteins, researchers can uncover potential therapeutic targets for the treatment of these disorders, and develop innovative strategies to modulate synaptic transmission and promote healthy brain function.
| Antibody Name: | SYT1/SYT2 (Ab-202/199) Antibody (PACO22975) |
| Antibody SKU: | PACO22975 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IF:1:100-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Peptide sequence around aa.200~204/197~201 (R-K-T-L-N) derived from Human Synaptotagmin 1/2. |
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Hela cells using Synaptotagmin 1/2(Ab-202/199) Antibody and the same antibody preincubated with blocking peptide. |
 | Immunofluorescence staining of methanol-fixed Hela cells using Synaptotagmin 1/2(Ab-202/199) Antibody. |
| Background: | The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse |
| Synonyms: | SYT1/2; SytI/II; Synaptotagmin I/II; P65; SYT |
| UniProt Protein Function: | SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle; Calcium-binding Chromosomal Location of Human Ortholog: 12cen-q21 Cellular Component: neuron projection; plasma membrane; synaptic vesicle; synaptic vesicle membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SNARE binding; syntaxin-1 binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; detection of calcium ion; glutamate secretion; neurotransmitter secretion; positive regulation of synaptic transmission; protein homooligomerization; regulation of calcium ion-dependent exocytosis; regulation of exocytosis; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic vesicle endocytosis; vesicle fusion |
| NCBI Summary: | The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010] |
| UniProt Code: | P21579 |
| NCBI GenInfo Identifier: | 135086 |
| NCBI Gene ID: | 6857 |
| NCBI Accession: | P21579.1 |
| UniProt Secondary Accession: | P21579,Q6AI31, |
| UniProt Related Accession: | P21579 |
| Molecular Weight: | 47,573 Da |
| NCBI Full Name: | Synaptotagmin-1 |
| NCBI Synonym Full Names: | synaptotagmin 1 |
| NCBI Official Symbol: | SYT1Â Â |
| NCBI Official Synonym Symbols: | P65; SYT; SVP65Â Â |
| NCBI Protein Information: | synaptotagmin-1 |
| UniProt Protein Name: | Synaptotagmin-1 |
| UniProt Synonym Protein Names: | Synaptotagmin I; SytI; p65 |
| Protein Family: | Synaptotagmin |
| UniProt Gene Name: | SYT1Â Â |
| UniProt Entry Name: | SYT1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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