The Syntaxin-1A Polyclonal Antibody (CAB7931) is a vital tool for researchers studying Syntaxin-1A, a protein involved in synaptic vesicle exocytosis. This antibody, produced in rabbits, demonstrates high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to the Syntaxin-1A protein, this antibody enables precise detection and analysis in various cell types, facilitating research in neurobiology and neuroscience.Syntaxin-1A plays a crucial role in neurotransmitter release at the synapse, making it a key player in neuronal communication and synaptic transmission.
Dysfunction of Syntaxin-1A has been implicated in neurological disorders such as epilepsy, schizophrenia, and neurodegenerative diseases. Therefore, understanding the function and regulation of Syntaxin-1A is essential for developing potential therapeutic interventions targeting these conditions.Overall, the Syntaxin-1A Polyclonal Antibody (CAB7931) offers researchers a valuable tool for investigating the role of Syntaxin-1A in neuronal function and dysfunction, paving the way for potential advancements in the understanding and treatment of neurological disorders.
Product Name:
STX1A Rabbit Polyclonal Antibody
SKU:
CAB7931
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human STX1A (Q16623).
Cell junction, Cell membrane, Cytoplasmic vesicle, Secreted, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
Calculated MW:
33kDa
Observed MW:
38kDa
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6804
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using STX1A Rabbit pAb (CAB7931) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
