UniProt Protein Function: | DMN: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Belongs to the intermediate filament family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q26.3Cellular Component: adherens junction; costamere; intermediate filament; membrane; neurofilament cytoskeletonMolecular Function: intermediate filament binding; protein binding; structural constituent of cytoskeleton; structural constituent of muscle; vinculin bindingBiological Process: intermediate filament cytoskeleton organization and biogenesis |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15061 |
NCBI GenInfo Identifier: | 20137613 |
NCBI Gene ID: | 23336 |
NCBI Accession: | O15061.2 |
UniProt Secondary Accession: | O15061,Q2TBJ4, Q5NJJ9, Q8TE61, Q8TE62, A7E2Y2 |
UniProt Related Accession: | O15061 |
Molecular Weight: | 39,042 Da |
NCBI Full Name: | Synemin |
NCBI Synonym Full Names: | synemin |
NCBI Official Symbol: | SYNMÂ Â |
NCBI Official Synonym Symbols: | DMN; SYNÂ Â |
NCBI Protein Information: | synemin |
UniProt Protein Name: | Synemin |
UniProt Synonym Protein Names: | Desmuslin |
Protein Family: | |
UniProt Gene Name: | SYNMÂ Â |
UniProt Entry Name: | SYNEM_HUMAN |