The SYNM Antibody (PAC053742) is a polyclonal antibody designed for research involving SYNM, a protein involved in synapse formation and neuronal development. This antibody, produced in rabbits, is highly specific and reactive with human samples, validated for use in various applications including immunofluorescence and immunohistochemistry.SYNM, also known as synemin, is a cytoskeletal protein found in neurons and muscle cells, playing a crucial role in maintaining cell structure and function. Its involvement in synapse formation makes it a key player in processes related to neuronal development and connectivity.
Research on SYNM is important for understanding neurodevelopmental disorders, neurodegenerative diseases, and muscle dysfunction.With the SYNM Antibody, researchers can detect and analyze SYNM expression in a variety of cell types and tissues, providing valuable insights into its function and role in neurological and muscular health. This antibody is a valuable tool for studies focusing on synaptic organization, neuronal differentiation, and muscle cell structure, advancing our understanding of these complex biological processes.
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO53742 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO53742 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Synonyms:
Synemin (Desmuslin), SYNM, DMN KIAA0353 SYN
UniProt Protein Function:
DMN: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Belongs to the intermediate filament family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q26.3Cellular Component: adherens junction; costamere; intermediate filament; membrane; neurofilament cytoskeletonMolecular Function: intermediate filament binding; protein binding; structural constituent of cytoskeleton; structural constituent of muscle; vinculin bindingBiological Process: intermediate filament cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
