The SYNJ1 Polyclonal Antibody (CAB17581) is a valuable tool for research focusing on SYNJ1, a key protein involved in synaptic vesicle trafficking and membrane dynamics. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to SYNJ1, allowing for accurate detection and analysis in various cell types.SYNJ1, also known as synaptojanin-1, plays a crucial role in regulating synaptic vesicle endocytosis and recycling, essential processes for proper neurotransmission in the brain.
Dysregulation of SYNJ1 has been implicated in neurological disorders such as Parkinson's disease and Alzheimer's disease, making it an intriguing target for further research.By studying SYNJ1 with this polyclonal antibody, researchers can gain insight into the molecular mechanisms underlying synaptic vesicle dynamics and potentially identify new therapeutic targets for neurological disorders. Its high reactivity and specificity make it a valuable tool for studies in neuroscience and neurodegenerative diseases.
Product Name:
SYNJ1 Rabbit Polyclonal Antibody
SKU:
CAB17581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SYNJ1 (NP_003886.3).
clathrin coat of coated pit, cytosol, membrane coat, parallel fiber to Purkinje cell synapse, perinuclear region of cytoplasm, presynapse, synaptic membrane, terminal bouton
Calculated MW:
173kDa
Observed MW:
140kDa
This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8867
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SYNJ1 Rabbit pAb (CAB17581) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
