SynGAP Rabbit Monoclonal Antibody (CAB19581)
- SKU:
- CAB19581
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MRD5
- RASA1
- RASA5
- SYNGAP
Description
Product Name: | SynGAP Rabbit Monoclonal Antibody |
SKU: | CAB19581 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1244-1343 of human SynGAP (Q96PV0). |
Sequence: | SEKR LRQQ QAEK DSQI KSII GRLM LVEE ELRR DHPA MAEP LPEP KKRL LDAQ ERQL PPLG PTNP RVTL APPW NGLA PPAP PPPP RLQI TENG EFRN TADH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MRD5; RASA1; RASA5; SYNGAP; SynGAP |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytosol, dendritic shaft, Glutamatergic synapse, plasma membrane, Postsynaptic density |
Calculated MW: | 148kDa |
Observed MW: | 140kDa |
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8831 |
Clone Number: | ARC2183 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |