The SYNE4 Polyclonal Antibody (PACO39390) is a valuable tool for researchers studying SYNE4, a protein involved in nuclear organization and cytoskeletal dynamics. This antibody, produced in rabbits, is highly specific for detecting SYNE4 in human samples and has been validated for use in various applications, including Western blotting.SYNE4 is a key player in maintaining the structure and function of the nucleus, as well as mediating interactions between the nucleus and the cytoskeleton. Dysregulation of SYNE4 has been implicated in various diseases, including cancer and neurological disorders.
By using the SYNE4 Polyclonal Antibody, researchers can better understand the role of SYNE4 in these pathological processes and potentially identify new therapeutic targets.Overall, the SYNE4 Polyclonal Antibody is a reliable tool for investigating the function of SYNE4 in cellular processes and disease pathogenesis, making it a valuable asset for researchers in the fields of cell biology, cancer research, and neuroscience.
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus.
Synonyms:
Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4), SYNE4, C19orf46
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
