The Syncytin-2 Polyclonal Antibody (CAB10162) is a valuable tool for researchers studying Syncytin-2, a retroviral envelope protein involved in cell-cell fusion and placental development. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to Syncytin-2, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in developmental biology and reproductive health.Syncytin-2 is a key player in placental formation and function, playing a crucial role in the fusion of trophoblast cells to form the syncytiotrophoblast layer essential for nutrient exchange between mother and fetus.
Dysregulation of Syncytin-2 has been implicated in various pregnancy complications and reproductive disorders, highlighting its importance in understanding reproductive biology and prenatal health. By targeting Syncytin-2, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for improving reproductive outcomes.
Product Name:
ERVFRD-1 Rabbit Polyclonal Antibody
SKU:
CAB10162
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 16-250 of human ERVFRD-1 (NP_997465.1).
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.
Purification Method:
Affinity purification
Gene ID:
405754
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of 293T cells, using ERVFRD-1 antibody (CAB10162) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
