The Synaptotagmin 4 Polyclonal Antibody (CAB7737) is specifically designed for researchers studying Synaptotagmin 4, a crucial protein involved in synaptic vesicle trafficking and exocytosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Synaptotagmin 4 is essential for the regulation of neurotransmitter release at synapses, making it a key player in neuronal communication. By binding to the Synaptotagmin 4 protein, this antibody enables researchers to detect and analyze its expression in various cell types, offering valuable insights into the mechanisms underlying synaptic transmission.
The role of Synaptotagmin 4 in synaptic vesicle fusion and neurotransmitter release makes it a promising target for studies aiming to understand neurophysiology and neurological disorders. By deepening our understanding of Synaptotagmin 4 function, researchers can potentially uncover new therapeutic strategies for conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
Product Name:
SYT4 Rabbit Polyclonal Antibody
SKU:
CAB7737
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 38-190 of human SYT4 (NP_065834.1).
Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in negative regulation of catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in several cellular components, including microvesicle; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including axon; exocytic vesicle; and glutamatergic synapse. Predicted to be integral component of neuronal dense core vesicle membrane.
Purification Method:
Affinity purification
Gene ID:
6860
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SYT4 Rabbit pAb (CAB7737) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
