The SUV39H1 Polyclonal Antibody (CAB3277) is a valuable tool for researchers studying SUV39H1, a histone methyltransferase known for its role in chromatin remodeling and gene regulation. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it a reliable choice for Western blotting experiments.SUV39H1 is a key player in epigenetic regulation, particularly in the process of histone methylation and gene silencing. Dysregulation of SUV39H1 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.
The SUV39H1 Polyclonal Antibody enables precise detection and analysis of SUV39H1 expression levels in different cell types, providing insights into its function and potential implications in disease pathology.By using this antibody, researchers can further investigate the intricate mechanisms of SUV39H1-mediated gene regulation and chromatin modifications, paving the way for novel discoveries in the fields of epigenetics, oncology, and neurobiology. Its versatility and reliability make it an essential tool for unravelling the complex role of SUV39H1 in health and disease.
Product Name:
SUV39H1 Rabbit Polyclonal Antibody
SKU:
CAB3277
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SUV39H1 (NP_003164.1).
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6839
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SUV39H1 antibody (CAB3277) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
