UniProt Protein Function: | SUSD6: May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset. {ECO:0000250|UniProtKB:Q8BGE4, ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}. Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. {ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}Protein type: Membrane protein, integral; Tumor suppressorChromosomal Location of Human Ortholog: 14q24.1Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: cell death; response to DNA damage stimulus |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q92537 |
NCBI GenInfo Identifier: | 7662020 |
NCBI Gene ID: | 9766 |
NCBI Accession: | NP_055549.1 |
UniProt Secondary Accession: | Q92537 |
UniProt Related Accession: | Q92537 |
Molecular Weight: | 32,090 Da |
NCBI Full Name: | sushi domain-containing protein 6 |
NCBI Synonym Full Names: | sushi domain containing 6 |
NCBI Official Symbol: | SUSD6Â Â |
NCBI Official Synonym Symbols: | DRAGO; KIAA0247Â Â |
NCBI Protein Information: | sushi domain-containing protein 6 |
UniProt Protein Name: | Sushi domain-containing protein 6 |
UniProt Synonym Protein Names: | Drug-activated gene overexpressed protein |
Protein Family: | Sushi domain-containing protein |
UniProt Gene Name: | SUSD6Â Â |
UniProt Entry Name: | SUSD6_HUMAN |