The SUSD6 Polyclonal Antibody (PAC038390) is a valuable tool for researchers studying SUSD6, a cell surface protein involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SUSD6 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an essential tool for investigations in the fields of immunology, cancer biology, and beyond.
SUSD6, also known as sushi domain-containing protein 6, is implicated in processes such as cell adhesion, migration, and signaling, indicating its potential relevance in disease mechanisms. Research into SUSD6 function may provide valuable insights into pathologies such as cancer, developmental disorders, and immune-related conditions. By elucidating the role of SUSD6 in these contexts, researchers may uncover new therapeutic targets and strategies for disease intervention.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO38390 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO38390 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset.
SUSD6: May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset. {ECO:0000250|UniProtKB:Q8BGE4, ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}. Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. {ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}Protein type: Membrane protein, integral; Tumor suppressorChromosomal Location of Human Ortholog: 14q24.1Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: cell death; response to DNA damage stimulus
