The Survivin Rabbit Monoclonal Antibody (CAB4838) is a cutting-edge tool for researchers focusing on the protein survivin, a key player in the regulation of cell division and apoptosis. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity in detecting survivin in human samples, making it a reliable choice for Western blot applications. By targeting survivin, researchers can delve into its role in cancer biology, particularly in cell proliferation and survival pathways.Survivin is a member of the inhibitor of apoptosis (IAP) family, known for its dual function in promoting cell survival and inhibiting programmed cell death.
Its overexpression has been linked to tumorigenesis and resistance to cancer therapies, underscoring its potential as a therapeutic target in oncology. By utilizing the Survivin Rabbit Monoclonal Antibody, researchers can uncover the intricate mechanisms underlying survivin's contributions to cancer progression, paving the way for the development of novel treatment strategies.
Product Name:
Survivin Rabbit Monoclonal Antibody
SKU:
CAB4838
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human Survivin (O15392).
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
332
Clone Number:
ARC0259
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Survivin Rabbit mAb (CAB4838) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min.
