The Survivin Monoclonal Antibody is a cutting-edge tool for researchers investigating the protein survivin, a key player in cell division, apoptosis, and cancer development. This monoclonal antibody is specifically designed to target survivin in human samples, providing reliable results for a variety of research applications, including immunohistochemistry and flow cytometry.Survivin is a unique protein that regulates cell division and inhibits apoptosis, making it a highly interesting target for cancer research. Studies have shown that survivin is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and resistance to chemotherapy.
By using the Survivin Monoclonal Antibody, researchers can gain valuable insights into the role of this protein in cancer development and progression.Overall, the Survivin Monoclonal Antibody is a powerful tool for researchers looking to delve deeper into the mechanisms of cancer and develop new strategies for diagnosis and treatment. Its high specificity and sensitivity make it an essential component of any cancer research toolkit.
Product Name:
Survivin Monoclonal Antibody
SKU:
CAB22034
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human Survivin (NP_001159.2).
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
332
Clone Number:
ARC54647
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Survivin antibody (CAB22034) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
