Surfactant Protein A/SP-A Polyclonal Antibody (CAB24870)
The Surfactant Protein A (SP-A) Polyclonal Antibody is a valuable tool for researchers studying the role of SP-A in lung health and immunity. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blotting.Surfactant Protein A is a key component of the pulmonary surfactant system, playing a crucial role in lung defense and the innate immune response. Research has shown that SP-A is involved in pathogen recognition, modulation of inflammation, and regulation of immune cell function in the lungs.
By utilizing the SP-A Polyclonal Antibody, researchers can detect and analyze SP-A expression in different cell types and tissues, aiding in the investigation of respiratory diseases, immune disorders, and infections. Understanding the function of SP-A can provide insights into potential therapeutic targets for various respiratory conditions and help improve treatment strategies for patients.
Product Name:
Surfactant Protein A/SP-A Polyclonal Antibody
SKU:
CAB24870
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-248 of human SFTPA1 (NP_001158116.1).
Secreted, extracellular matrix, extracellular space, surface film.
Calculated MW:
26kDa
Observed MW:
30-38kDa
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
653509/729238
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung using Surfactant Protein A/SP-A Rabbit pAb(CAB24870) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:20s.
