The SURA Antibody (PACO34790) is a highly specific polyclonal antibody designed for research involving CD300A, a cell surface molecule known for its role in immune regulation. Raised in rabbits, this antibody is particularly reactive with human samples and has been validated for use in Western blot applications. By binding to the CD300A protein, it enables accurate detection and analysis in a variety of cell types, making it an invaluable tool for studies in immunology and cancer research.CD300A, also referred to as an immune inhibitory receptor, is crucial for maintaining immune homeostasis by regulating inflammation and suppressing allergic reactions.
Its involvement in immune response modulation highlights its importance as a target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Gaining insights into the functions of CD300A is essential for developing therapies that can either leverage or modulate immune function in these disease contexts.
Antibody Name:
surA Antibody (PACO34790)
Antibody SKU:
PACO34790
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Chaperone SurA protein (21-428AA)
Western blot. All lanes: surA antibody at 12µg/ml. Lane 1: 293T whole cell lysate. Lane 2: DH5alpha whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa.
Background:
Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis.
Synonyms:
Chaperone SurA (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (EC 5.2.1.8) (Rotamase SurA) (Survival protein A), surA
UniProt Protein Function:
Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis.
UniProt Protein Details:
NCBI Summary:
Parvulin (ppiC) family. [More information is available at EcoGene: EG10985]. SurA in Escherichia coli is a periplasmic peptidyl-prolyl isomerase which is necessary for the proper folding of outer membrane proteins including OmpA, OmpF and LamB. [More information is available at EcoCyc: EG10985].
