The Sun2 Polyclonal Antibody (CAB16325) is a valuable tool for researchers studying the nuclear envelope protein Sun2. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By specifically binding to the Sun2 protein, this antibody enables precise detection and analysis in a range of cell types.Sun2 is a critical component of the nuclear envelope, playing a key role in nuclear positioning and anchoring. Dysregulation of Sun2 has been implicated in various diseases, including cancer and muscular dystrophy, making it a promising target for further investigation.
By studying the function of Sun2 with the Sun2 Polyclonal Antibody, researchers can gain valuable insights into cellular processes and potential therapeutic targets for related disorders.Overall, the Sun2 Polyclonal Antibody (CAB16325) offers researchers a reliable tool for exploring the role of Sun2 in health and disease, with implications for advancing our understanding of nuclear envelope function and potential therapeutic interventions.
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).
Purification Method:
Affinity purification
Gene ID:
25777
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SUN2 Rabbit pAb (CAB16325) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
