The SUN1 Polyclonal Antibody (PAC062011) is a valuable tool for researchers investigating the nuclear envelope protein SUN1. This antibody, raised in rabbits, is highly specific and reactive to human samples, making it an essential component for studying the localization and function of SUN1 in various cellular processes.SUN1 is a key player in nuclear envelope dynamics and has been implicated in nuclear migration, meiosis, and chromosome movement. By targeting the SUN1 protein, this antibody enables researchers to visualize and analyze the distribution and behavior of SUN1 in different cell types, facilitating studies in cell biology, meiosis, and development.
Understanding the role of SUN1 in nuclear envelope structure and function is essential for uncovering its involvement in various cellular processes and diseases. The SUN1 Polyclonal Antibody provides researchers with a reliable tool to further explore the functions and interactions of SUN1, ultimately contributing to advancements in the field of cell biology and genetics.
Antibody Name:
SUN1 Antibody (PACO62011)
Antibody SKU:
PACO62011
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana SUN domain-containing protein 1 protein (2-105AA)
Western Blot. Positive WB detected in: Spinacia oleracea leaf tissue. All lanes: SUN1 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52 kDa. Observed band size: 52 kDa.
Background:
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for the maintenance and/or formation of polarized nuclear shape in root hairs. Modulates the anchoring and mobility of WIP proteins and RANGAP1 in the nuclear envelope (NE). In association with SUN2, may be involved in telomere attachment to nuclear envelope in the prophase of meiosis. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Synonyms:
SUN domain-containing protein 1 (AtSUN1), SUN1
UniProt Protein Function:
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (PubMed:24667841, PubMed:25759303). Required for the maintenance and/or formation of polarized nuclear shape in root hairs (PubMed:21294795, PubMed:25759303). Modulates the anchoring and mobility of WIP proteins and RANGAP1 in the nuclear envelope (NE) (PubMed:22270916). In association with SUN2, may be involved in telomere attachment to nuclear envelope in the prophase of meiosis (PubMed:25412930). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).
UniProt Protein Details:
NCBI Summary:
Encodes a member of the Sad1/UNC-84 (SUN)-domain proteins: AtSUN1(At5g04990), AtSUN2(AT3G10730). SUN domain proteins are part of the cytoskeletal-nucleoskeletal bridging complexes. AtSUN1 and AtSUN2 are localized to the nuclear envelope and are present as homomers and heteromers in vivo.Encodes an outer nuclear membrane protein that anchors RanGAP1 to the nuclear envelope. It interacts with WPP domain interacting-proteins (WIPs). It is involved in maintaining the elongated nuclear shape of epidermal cells.
