The SUMO4 Polyclonal Antibody (CAB7517) is a crucial tool for researchers studying the SUMO4 protein, a member of the Small Ubiquitin-like Modifier (SUMO) family that plays a key role in post-translational modification. The antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications.SUMO4 is involved in various cellular processes, including protein stability, protein-protein interactions, and gene transcription regulation. Dysregulation of SUMO4 has been linked to various diseases, such as cancer, neurodegenerative disorders, and autoimmune conditions.
By targeting SUMO4 with this antibody, researchers can investigate its function and potential role in disease pathogenesis, paving the way for the development of targeted therapies.With its ability to detect and analyze SUMO4 in different cell types, this polyclonal antibody is a valuable tool for advancing research in the fields of molecular biology, cell biology, and disease mechanisms. By understanding the intricacies of SUMO4 biology, researchers can uncover new insights into disease progression and potentially identify novel therapeutic strategies.
Product Name:
SUMO4 Rabbit Polyclonal Antibody
SKU:
CAB7517
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human SUMO4 (NP_001002255.1).
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
Purification Method:
Affinity purification
Gene ID:
387082
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SUMO4 antibody (CAB7517) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 40s.
