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SUMO2/3 Monoclonal Antibody [PAT10F1AT] (CPAB0433)

SKU:
CPAB0433
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT10F1AT
Applications:
WB
IF
ELISA
€149

Description

system_update_alt Datasheet

SUMO2/3 Monoclonal Antibody [PAT10F1AT] (CPAB0433)

The SUMO2/3 Antibody (CPAB0433) is a valuable tool for researchers studying protein SUMOylation, a post-translational modification that plays a key role in cellular processes such as DNA repair, transcriptional regulation, and protein localization. This antibody, raised against SUMO2/3, demonstrates high specificity and sensitivity in Western blot applications, allowing for the detection and analysis of SUMO2/3-conjugated proteins in various cell types.SUMOylation is involved in the regulation of numerous cellular pathways, including stress responses, signal transduction, and protein quality control.

Dysregulation of SUMOylation has been implicated in various diseases, making it a promising target for therapeutic interventions. The SUMO2/3 Antibody provides researchers with a reliable tool for investigating the dynamic and complex role of SUMOylation in health and disease, offering insights that may lead to the development of novel treatment strategies.

Product Name:SUMO2/3 Antibody
Product Sku:CPAB0433
Size:5μg
Host Species:Mouse
Immunogen:Anti-human SUMO2/3 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SUMO2 amino acids 1-93 purified from Ecoli.
Clone:PAT10F1AT.
Reactivity:Other bodies
Applications:Western Blot, Immunofluorescence, ELISA
Purification Method:SUMO2/3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Small Ubiquitin-like Modifiers (SUMOs) are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. Unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. All SUMO proteins share the conserved ubiquitin domain and the C-terminal diglycine cleavage/attachment site. Human SUMO2, also known as Sentrin2 and SMT3B is synthesized as a 95 amino acid (aa), 11 kDa propeptide that contains a two aa C-terminal prosegment, and an 18 aa N-terminal protein interacting region (aa 33 -50). Following prosegment cleavage, the C-terminal glycine is enzymatically attached to a lysine on a target protein. Human SUMO2 shares 100% sequence identity to SUMO-2 from mouse. SUMO2 also has very high sequence homology to SUMO3 and SUMO4, 86 % and 85%, respectivel
Synonyms:Small ubiquitin-related modifier 2, SUMO-2, Ubiquitin-like protein SMT3B, SMT3 homolog 2, Sentrin-2, HSMT3, SUMO-3, SUMO2, SMT3B, SMT3H2, MGC117191.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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