The SUMF1 Polyclonal Antibody (CAB14304) is a valuable tool for researchers studying SUMF1, a key enzyme involved in post-translational modification of proteins. This antibody, generated in rabbits, shows high specificity and sensitivity in detecting SUMF1 protein in human samples, making it ideal for use in Western blot applications.SUMF1 is essential for the activation of sulfatases, enzymes that play crucial roles in various cellular processes, including lysosomal function and extracellular matrix remodeling. Dysregulation of SUMF1 has been implicated in diseases such as multiple sulfatase deficiency and certain types of cancer.
By targeting SUMF1, researchers can gain insights into the mechanisms underlying these disorders and potentially develop targeted therapies.With its proven reliability and efficacy in detecting SUMF1, the CAB14304 antibody is a valuable tool for studies in biochemistry, cell biology, and disease research. Its ability to accurately identify and analyze SUMF1 protein levels in different cell types makes it a valuable asset for exploring the roles of SUMF1 in health and disease.
Product Name:
SUMF1 Rabbit Polyclonal Antibody
SKU:
CAB14304
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 34-374 of human SUMF1 (NP_877437.2).
This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
285362
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SUMF1 Rabbit pAb (CAB14304) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
