The SULT1B1 Antibody (PAC017173) is a highly specific research tool designed for studying SULT1B1, an enzyme involved in the metabolism of various endogenous and exogenous compounds. This polyclonal antibody, raised against SULT1B1, is suitable for use in various research applications such as Western blot and immunohistochemistry.SULT1B1 is a sulfotransferase enzyme that plays a crucial role in the process of sulfation, which is important for the detoxification and elimination of xenobiotics and endogenous compounds. The expression and activity of SULT1B1 have been implicated in drug metabolism, chemical carcinogenesis, and hormone regulation.By utilizing the SULT1B1 Antibody (PAC017173), researchers can explore the expression levels and localization of SULT1B1 in different tissues and cell types.
This antibody enables accurate detection and analysis of SULT1B1, making it a valuable tool for investigating the roles of sulfation pathways in drug metabolism, toxicology, and disease processes.Overall, the SULT1B1 Antibody (PAC017173) is a reliable resource for researchers interested in studying the functions and regulation of SULT1B1 in various biological processes. Its specificity and sensitivity make it a valuable asset for a wide range of research studies related to drug metabolism, xenobiotic detoxification, and chemical biology.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17173(SULT1B1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue, Primary antibody: PACO17173(SULT1B1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17173(SULT1B1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes.
Synonyms:
sulfotransferase family, cytosolic, 1B, member 1
UniProt Protein Function:
SULT1B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Belongs to the sulfotransferase 1 family.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
