SULT1B1 Antibody (PACO12578)
- SKU:
- PACO12578
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SULT1B1 Antibody (PACO12578)
The SULT1B1 Polyclonal Antibody (PACO12578) is a valuable tool designed for research involving SULT1B1, a sulfotransferase enzyme involved in the metabolism of various endogenous and exogenous compounds. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blotting.SULT1B1 plays a crucial role in the sulfonation of substrates, including hormones, drugs, and environmental toxins, making it a key player in drug metabolism and detoxification processes. This antibody binds specifically to the SULT1B1 protein, enabling accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in pharmacology, toxicology, and drug development.
Understanding the function and regulation of SULT1B1 is essential for advancing our knowledge of drug metabolism pathways and the impact of genetic variations on individual responses to medications. Research using this polyclonal antibody can provide valuable insights into the role of SULT1B1 in drug efficacy, toxicity, and personalized medicine approaches.
| Antibody Name: | SULT1B1 Antibody (PACO12578) |
| Antibody SKU: | PACO12578 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human SULT1B1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | sulfotransferase family, cytosolic, 1B, member 1;SULT1B1;MGC13356;ST1B2;SULT1B2 ; |
| UniProt Protein Function: | SULT1B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.-; Transferase Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytosol Molecular Function:sulfotransferase activity; aryl sulfotransferase activity Biological Process: steroid metabolic process; biogenic amine metabolic process; epithelial cell differentiation; flavonoid metabolic process; xenobiotic metabolic process; sulfation; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; thyroid hormone metabolic process; phenol metabolic process |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43704 |
| NCBI GenInfo Identifier: | 57013032 |
| NCBI Gene ID: | 27284 |
| NCBI Accession: | O43704.2 |
| UniProt Secondary Accession: | O43704,O15497, Q96FI1, Q9UK34, |
| UniProt Related Accession: | O43704 |
| Molecular Weight: | 296 |
| NCBI Full Name: | Sulfotransferase family cytosolic 1B member 1 |
| NCBI Synonym Full Names: | sulfotransferase family, cytosolic, 1B, member 1 |
| NCBI Official Symbol: | SULT1B1Â Â |
| NCBI Official Synonym Symbols: | ST1B1; ST1B2; SULT1B2Â Â |
| NCBI Protein Information: | sulfotransferase family cytosolic 1B member 1; sulfotransferase 1B1; sulfotransferase 1B2; thyroid hormone sulfotransferase |
| UniProt Protein Name: | Sulfotransferase family cytosolic 1B member 1 |
| UniProt Synonym Protein Names: | Sulfotransferase 1B2; ST1B2; Thyroid hormone sulfotransferase |
| Protein Family: | Sulfotransferase family cytosolic |
| UniProt Gene Name: | SULT1B1Â Â |
| UniProt Entry Name: | ST1B1_HUMAN |
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