The SULA Polyclonal Antibody (PACO34930) is a crucial tool for researchers studying the SULA protein, a key player in various cellular processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SULA protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cell signaling pathways.
SULA, also known as a potential regulator of cell growth and proliferation, is involved in important cellular functions such as DNA replication and repair. Its role in these processes makes it a promising target for research in cancer biology, genetic diseases, and developmental biology. Understanding the function of SULA can provide valuable insights into disease mechanisms and pathways, ultimately paving the way for the development of new therapeutic strategies.
Antibody Name:
sulA Antibody (PACO34930)
Antibody SKU:
PACO34930
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Cell division inhibitor SulA protein (1-169AA)
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. The effect of overexpression of SulA is neutralized by antitoxin CbeA (yeeU).
Synonyms:
Cell division inhibitor SulA, sulA, sfiA
UniProt Protein Function:
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. The effect of overexpression of SulA is neutralized by antitoxin CbeA (yeeU) (PubMed:22515815).
UniProt Protein Details:
NCBI Summary:
Regulation has been described . sulA mRNA stability during glucose starvation is diminished in the absence of |FRAME: [More information is available at EcoCyc: EG10984].
