The SUFU Polyclonal Antibody (CAB6757) is a valuable tool for researchers studying the SUFU protein, a key player in the hedgehog signaling pathway. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the SUFU protein, this antibody enables researchers to detect and analyze SUFU expression in various cell types, making it an essential component in studies related to developmental biology, cancer research, and stem cell regulation.SUFU is a critical regulator of the hedgehog signaling pathway, which plays a crucial role in embryonic development, tissue patterning, and stem cell maintenance.
Dysregulation of this pathway has been implicated in various diseases, including cancer and developmental disorders. By studying the function of SUFU, researchers can gain important insights into the molecular mechanisms underlying these conditions and potentially uncover new therapeutic targets.Overall, the SUFU Polyclonal Antibody (CAB6757) offers researchers a reliable tool for investigating the role of SUFU in various biological processes, paving the way for new discoveries and advancements in the field of molecular biology and therapeutic development.
Product Name:
SUFU Rabbit Polyclonal Antibody
SKU:
CAB6757
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 325-484 of human SUFU (NP_057253.2).
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SUFU Rabbit pAb (CAB6757) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
