The SUFU Polyclonal Antibody (CAB13429) is specifically designed for research involving SUFU, a critical component of the Hedgehog signaling pathway. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It binds to the SUFU protein, allowing for the detection and analysis of SUFU in various cell types, making it an ideal tool for studies in developmental biology and cancer research.SUFU plays a crucial role in regulating the Hedgehog signaling pathway, which is essential for embryonic development and tissue homeostasis. Dysregulation of this pathway has been linked to various types of cancer, making SUFU a valuable target for research in oncology.
Studying the function of SUFU can provide insights into the mechanisms underlying tumorigenesis and potentially lead to the development of novel therapeutic strategies targeting the Hedgehog pathway.Overall, the SUFU Polyclonal Antibody is a valuable tool for researchers interested in studying the Hedgehog signaling pathway and its implications in cancer biology. Its high reactivity and specificity make it ideal for investigating the role of SUFU in both normal development and disease states, ultimately advancing our understanding of complex biological processes.
Product Name:
SUFU Rabbit Polyclonal Antibody
SKU:
CAB13429
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 325-484 of human SUFU (NP_057253.2).
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse testis using SUFU Rabbit pAb(CAB13429) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
