The Succinylation Histone H3 K79 Rabbit Polyclonal Antibody (CAB17903) is a valuable tool for researchers studying post-translational modifications of histone proteins. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.Histone H3 K79 succinylation is a key modification involved in gene regulation and chromatin remodeling, impacting processes such as transcription and DNA repair. This antibody specifically binds to histone H3 K79 succinylated protein, allowing for precise detection and analysis in different cell types.
It is an essential resource for studies in epigenetics, cancer research, and other areas where histone modifications play a crucial role.By investigating the role of histone H3 K79 succinylation and its impact on gene expression and cellular functions, researchers can gain insights into various diseases and potentially identify new therapeutic targets. This antibody provides a reliable tool for exploring the complex interplay between histone modifications and cellular processes, furthering our understanding of epigenetic regulation.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Purification Method:
Affinity purification
Gene ID:
8290/8350
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using succinylation-Histone H3-K79 Rabbit pAb (CAB17903) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
