The STT3A Antibody (PAC012551) is a high-quality polyclonal antibody designed for research involving STT3A, a key component of the oligosaccharyltransferase (OST) complex that catalyzes the transfer of preassembled oligosaccharides to nascent polypeptides in the endoplasmic reticulum. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications.STT3A plays a critical role in protein glycosylation, a post-translational modification essential for protein folding, stability, and function. Dysregulation of glycosylation has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders.
The STT3A Antibody enables the detection and analysis of STT3A protein levels in different cell types, providing valuable insights into the role of protein glycosylation in cellular processes.The STT3A Antibody is a valuable tool for researchers in the fields of biochemistry, cell biology, and molecular biology, offering a reliable means to study the mechanisms of protein glycosylation and its implications in health and disease. By elucidating the functions of STT3A, researchers can advance our understanding of protein quality control and potentially identify novel therapeutic targets for intervention in glycosylation-related disorders.
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae);STT3A;FLJ27038;ITM1;MGC9042;STT3-A;TMC ;
UniProt Protein Function:
ITM1: Catalytic component of oligosaccharyltransferase (OST) oligosaccharyltransferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. Belongs to the STT3 family.Protein type: Membrane protein, multi-pass; EC 2.4.99.18; Membrane protein, integral; Endoplasmic reticulum; TransferaseChromosomal Location of Human Ortholog: 11q23.3Cellular Component: endoplasmic reticulum membrane; membrane; oligosaccharyl transferase complexMolecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; protein bindingBiological Process: co-translational protein modification; post-translational protein modification; protein amino acid N-linked glycosylation via asparagineDisease: Congenital Disorder Of Glycosylation, Type Iw
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
