The STRA8 Antibody (PAC018939) is a highly specific and sensitive tool for researchers studying the role of STRA8 in biological processes. STRA8, also known as stimulated by retinoic acid gene 8, is a protein involved in meiotic initiation and spermatogenesis.This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the STRA8 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it a valuable asset for studies in reproductive biology and developmental genetics.
STRA8 plays a crucial role in the regulation of germ cell development and fertility, making it a key target for research in reproductive health and infertility. Understanding the functions and mechanisms of STRA8 can provide insights into the molecular pathways underlying gametogenesis and may lead to potential therapeutic interventions for fertility issues and reproductive disorders.Overall, the STRA8 Antibody is a reliable tool for investigating the complex processes controlled by STRA8, offering researchers a deeper understanding of reproductive biology and potential implications for human health.
Antibody Name:
STRA8 Antibody (PACO18939)
Antibody SKU:
PACO18939
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human STRA8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18939(STRA8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18939(STRA8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a retinoic acid, responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans.
Synonyms:
stimulated by retinoic acid, 8
UniProt Protein Function:
STRA8: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.Chromosomal Location of Human Ortholog: 7q33Cellular Component: cytoplasm; nucleusMolecular Function: protein dimerization activityBiological Process: fertilization; meiotic cell cycle DNA replication checkpoint; ovarian follicle development; meiotic chromosome condensation; meiotic recombination; synapsis; meiotic DNA double-strand break formation; spermatogenesis; regulation of organ growth; female meiosis sister chromatid cohesion; DNA replication; oocyte development
UniProt Protein Details:
NCBI Summary:
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
