The STRA8 Antibody (PAC018938) is a vital tool for researchers studying the role of the Stimulated by Retinoic Acid 8 (STRA8) protein in cell differentiation and development. This monoclonal antibody is specifically designed for use in applications such as immunohistochemistry and western blotting, offering high specificity and sensitivity for detecting STRA8 in various biological samples.STRA8 is known for its critical function in the process of meiosis, playing a key role in germ cell development and fertility. By using this antibody, researchers can explore the expression and localization of STRA8 in different tissues, providing insights into its involvement in reproductive biology and potential implications for fertility treatments and contraception strategies.
With its ability to target and detect the STRA8 protein with precision, the STRA8 Antibody (PAC018938) is an essential tool for studies related to gametogenesis, reproductive health, and developmental biology. Its reliability and performance make it a valuable asset for advancing research in the field of reproductive sciences.
Antibody Name:
STRA8 Antibody (PACO18938)
Antibody SKU:
PACO18938
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human STRA8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18938(STRA8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18938(STRA8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a retinoic acid, responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans.
Synonyms:
stimulated by retinoic acid, 8
UniProt Protein Function:
STRA8: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.Chromosomal Location of Human Ortholog: 7q33Cellular Component: cytoplasm; nucleusMolecular Function: protein dimerization activityBiological Process: fertilization; meiotic cell cycle DNA replication checkpoint; ovarian follicle development; meiotic chromosome condensation; meiotic recombination; synapsis; meiotic DNA double-strand break formation; spermatogenesis; regulation of organ growth; female meiosis sister chromatid cohesion; DNA replication; oocyte development
UniProt Protein Details:
NCBI Summary:
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
