The STRA8 Antibody (PAC02222) is a polyclonal antibody designed for research involving STRA8, a protein involved in meiotic initiation and germ cell development. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it ideal for studying the function and regulation of STRA8 in various biological contexts. STRA8 is a key regulator of meiotic initiation, playing a critical role in the transition of germ cells from mitotic to meiotic divisions. Its expression is tightly regulated and essential for fertility in mammals. By targeting STRA8 with this antibody, researchers can investigate its role in reproductive biology, gametogenesis, and fertility.
The validation of this antibody for use in Western blot applications ensures accurate detection and analysis of STRA8 protein levels in different cell types and tissues. This makes it a valuable tool for studies in developmental biology, reproductive medicine, and fertility preservation. Understanding the functions of STRA8 could provide insights into infertility, reproductive disorders, and potential therapeutic interventions.
Antibody Name:
STRA8 Antibody
Antibody SKU:
PACO02222
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Stra8.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
STRA8; Stimulated by retinoic acid gene 8 protein homolog
UniProt Protein Function:
STRA8: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.Chromosomal Location of Human Ortholog: 7q33Cellular Component: cytoplasm; nucleusMolecular Function: protein dimerization activityBiological Process: fertilization; meiotic cell cycle DNA replication checkpoint; ovarian follicle development; meiotic chromosome condensation; meiotic recombination; synapsis; meiotic DNA double-strand break formation; spermatogenesis; regulation of organ growth; female meiosis sister chromatid cohesion; DNA replication; oocyte development
UniProt Protein Details:
NCBI Summary:
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
